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- Title
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?
- Authors
Wen, Haitao; Ting, Jenny P-Y; O'Neill, Luke A J
- Abstract
The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, interleukin 1β (IL-1β) and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, subsequent evidence has suggested that inflammasome activation influences many metabolic disorders, including atherosclerosis, type 2 diabetes, gout and obesity. Another feature of inflammation in general and the inflammasome specifically is that the activation process has a profound effect on aerobic glycolysis (the 'Warburg effect'). Here we explore how the Warburg effect might be linked to inflammation and inflammasome activation.
- Publication
Nature immunology, 2012, Vol 13, Issue 4, p352
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.2228