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- Title
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.
- Authors
Liang, Hong-Erh; Reinhardt, R Lee; Bando, Jennifer K; Sullivan, Brandon M; Ho, I-Cheng; Locksley, Richard M
- Abstract
Interleukin 4 (IL-4) and IL-13 are critical for responses to parasitic helminthes. We used genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T cells (TFH cells). In contrast, tissue type 2 helper T cells (TH2 cells) produced both cytokines. There was also divergent production of IL-4 and IL-13 among cells of the innate immune system, whereby basophils produced IL-4, whereas innate helper type 2 cells (Ih2 cells) produced IL-13. IL-13 production by TH2 and Ih2 cells was dependent on the transcription factor GATA-3, which was present in large amounts in these cells, and in contrast to the small amount of GATA-3 in TFH cells and basophils. The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity.
- Publication
Nature Immunology, 2012, Vol 13, Issue 1, p58
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.2182