We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells.
- Authors
Feng, Xiaoming; Wang, Haikun; Takata, Hiroshi; Day, Timothy J; Willen, Jessica; Hu, Hui
- Abstract
The molecular mechanisms that underlie T cell quiescence are poorly understood. Here we report that mature naive CD8(+) T cells lacking the transcription factor Foxp1 gained effector phenotype and function and proliferated directly in response to interleukin 7 (IL-7) in vitro. Foxp1 repressed expression of the IL-7 receptor α-chain (IL-7Rα) by antagonizing Foxo1 and negatively regulated signaling by the kinases MEK and Erk. Acute deletion of Foxp1 induced naive T cells to gain an effector phenotype and proliferate in lympho-replete mice. Foxp1-deficient naive CD8(+) T cells proliferated even in lymphopenic mice deficient in major histocompatibility complex class I. Our results demonstrate that Foxp1 exerts essential cell-intrinsic regulation of naive T cell quiescence, providing direct evidence that lymphocyte quiescence is achieved through actively maintained mechanisms that include transcriptional regulation.
- Publication
Nature immunology, 2011, Vol 12, Issue 6, p544
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.2034