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- Title
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.
- Authors
Biswas, Subhra K; Mantovani, Alberto
- Abstract
Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.
- Publication
Nature immunology, 2010, Vol 11, Issue 10, p889
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1937