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- Title
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.
- Authors
Hitomi, Kaori; Tahara-Hanaoka, Satoko; Someya, Satoru; Fujiki, Akira; Tada, Hideaki; Sugiyama, Tetsuya; Shibayama, Shiro; Shibuya, Kazuko; Shibuya, Akira
- Abstract
Anaphylaxis is a life-threatening immediate hypersensitivity reaction triggered by antigen capture by immunoglobulin E (IgE) bound to the high-affinity IgE receptor (FcvarepsilonRI) on mast cells. However, the regulatory mechanism of mast cell activation is not completely understood. Here we identify an immunoglobulin-like receptor, Allergin-1, that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM)-like domain, and show it was preferentially expressed on mast cells. Mouse Allergin-1 recruited the tyrosine phosphatases SHP-1 and SHP-2 and the inositol phosphatase SHIP. Coligation of Allergin-1 and FcvarepsilonRI suppressed IgE-mediated degranulation of bone marrow-derived cultured mast cells. Moreover, mice deficient in Allergin-1 developed enhanced passive systemic and cutaneous anaphylaxis. Thus, Allergin-1 suppresses IgE-mediated, mast cell-dependent anaphylaxis in mice.
- Publication
Nature immunology, 2010, Vol 11, Issue 7, p601
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1886