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- Title
MicroRNA miR-326 regulates T<sub>H</sub>-17 differentiation and is associated with the pathogenesis of multiple sclerosis.
- Authors
Changsheng Du; Chang Liu; Jiuhong Kang; Guixian Zhao; Zhiqiang Ye; Shichao Huang; Zhenxin Li; Zhiying Wu; Gang Pei
- Abstract
Interleukin 17 (IL-17)-producing T helper cells (TH-17 cells) are increasingly recognized as key participants in various autoimmune diseases, including multiple sclerosis. Although sets of transcription factors and cytokines are known to regulate TH-17 differentiation, the role of noncoding RNA is poorly understood. Here we identify a TH-17 cell–associated microRNA, miR-326, whose expression was highly correlated with disease severity in patients with multiple sclerosis and mice with experimental autoimmune encephalomyelitis (EAE). In vivo silencing of miR-326 resulted in fewer TH-17 cells and mild EAE, and its overexpression led to more TH-17 cells and severe EAE. We also found that miR-326 promoted TH-17 differentiation by targeting Ets-1, a negative regulator of TH-17 differentiation. Our data show a critical role for microRNA in TH-17 differentiation and the pathogenesis of multiple sclerosis.
- Publication
Nature Immunology, 2009, Vol 10, Issue 12, p1252
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.1798