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- Title
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands.
- Authors
Barbalat, Roman; Lau, Laura; Locksley, Richard M; Barton, Gregory M
- Abstract
Despite the paradigm that the innate immune system uses nucleic acid-specific receptors to detect viruses because of a lack of other conserved features, many viruses are recognized by Toll-like receptor 2 (TLR2) and TLR4. The relevance of this recognition for antiviral immunity remains largely unexplained. Here we report that TLR2 activation by viruses led to the production of type I interferon. TLR2-dependent induction of type I interferon occurred only in response to viral ligands, which indicates that TLR2 is able to discriminate between pathogen classes. We demonstrate that this specialized response was mediated by Ly6C(hi) inflammatory monocytes. Thus, the innate immune system can detect certain non-nucleic acid features of viruses and links this recognition to the induction of specific antiviral genes.
- Publication
Nature immunology, 2009, Vol 10, Issue 11, p1200
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1792