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- Title
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
- Authors
Duhen, Thomas; Geiger, Rebekka; Jarrossay, David; Lanzavecchia, Antonio; Sallusto, Federica
- Abstract
Interleukin 22 (IL-22) is a cytokine produced by the T(H)-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T(H)-17 and T helper type 1 (T(H)1) transcription factors RORgammat and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.
- Publication
Nature immunology, 2009, Vol 10, Issue 8, p857
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1767