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- Title
Foxp3<sup>+</sup> regulatory T cells: differentiation, specification, subphenotypes.
- Authors
Feuerer, Markus; Hill, Jonathan A.; Mathis, Diane; Benoist, Christophe
- Abstract
Regulatory T cells (Treg cells) characterized by expression of the transcription factor Foxp3 play a key role in immune homeostasis. Rather than a monomorphic population strictly determined by Foxp3 as a 'master regulator', the emerging view is one of Treg cells as a population with many levels of complexity. Several regulatory factors partake in the control of their transcriptional 'signature', with Foxp3 being a key regulator but insufficient and unnecessary to specify all aspects of the lineage. Distinct subphenotypes of Foxp3+ Treg cells are found in different anatomical locations. Some subphenotypes specifically control different facets of effector T cell function and, perhaps surprisingly, share transcriptional control elements with the very cells they regulate. This review will focus on these novel aspects of Treg cell diversity.
- Publication
Nature Immunology, 2009, Vol 10, Issue 7, p689
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.1760