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- Title
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils.
- Authors
Kang Chen; Weifeng Xu; Wilson, Melanie; Bing He; Miller, Norman W.; Bengtén, Eva; Edholm, Eva-Stina; Santini, Paul A.; Rath, Poonam; Chiu, April; Cattalini, Marco; Litzman, Jiri; Bussel, James B.; Bihui Huang; Meini, Antonella; Riesbeck, Kristian; Cunningham-Rundles, Charlotte; Plebani, Alessandro; Cerutti, Andrea
- Abstract
Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell–dependent and T cell–independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell–stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell–activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class–switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.
- Publication
Nature Immunology, 2009, Vol 10, Issue 8, p889
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.1748