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- Title
MHC class II–dependent basophil–CD4<sup>+</sup> T cell interactions promote T<sub>H</sub>2 cytokine–dependent immunity.
- Authors
Perrigoue, Jacqueline G.; Saenz, Steven A.; Siracusa, Mark C.; Allenspach, Eric J.; Taylor, Betsy C.; Giacomin, Paul R.; Nair, Meera G.; Yurong Du; Zaph, Colby; van Rooijen, Nico; Comeau, Michael R.; Pearce, Edward J.; Laufer, Terri M.; Artis, David
- Abstract
Dendritic cells can prime naive CD4+ T cells; however, here we demonstrate that dendritic cell–mediated priming was insufficient for the development of T helper type 2 cell–dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific CD4+ T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive CD4+ T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II–dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.
- Publication
Nature Immunology, 2009, Vol 10, Issue 7, p697
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.1740