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- Title
Basophils contribute to T<sub>H</sub>2-IgE responses in vivo via IL-4 production and presentation of peptide–MHC class II complexes to CD4<sup>+</sup> T cells.
- Authors
Yoshimoto, Tomohiro; Yasuda, Koubun; Tanaka, Hidehisa; Nakahira, Masakiyo; Imai, Yasutomo; Fujimori, Yoshihiro; Nakanishi, Kenji
- Abstract
Basophils express major histocompatibility complex class II, CD80 and CD86 and produce interleukin 4 (IL-4) in various conditions. Here we show that when incubated with IL-3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized, processed and presented antigen as complexes of peptide and major histocompatibility complex class II and produced IL-4. Intravenous administration of ovalbumin-pulsed basophils into naive mice 'preferentially' induced the development of naive ovalbumin-specific CD4+ T cells into T helper type 2 (TH2) cells. Mice immunized in this way, when challenged by intravenous administration of ovalbumin, promptly produced ovalbumin-specific IgG1 and IgE. Finally, intravenous administration of IgE complexes rapidly induced TH2 cells only in the presence of endogenous basophils, which suggests that basophils are potent antigen-presenting cells that 'preferentially' augment TH2-IgE responses by capturing IgE complex.
- Publication
Nature Immunology, 2009, Vol 10, Issue 7, p706
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.1737