We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.
- Authors
Franchi, Luigi; Eigenbrod, Tatjana; Muñoz-Planillo, Raúl; Nuñez, Gabriel
- Abstract
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC are critical components of the inflammasome that link microbial and endogenous 'danger' signals to caspase-1 activation. Several diseases are associated with dysregulated activation of caspase-1 and secretion of IL-1beta. Thus, understanding inflammasome pathways may provide insight into disease pathogenesis that might identify potential targets for therapeutic intervention.
- Publication
Nature immunology, 2009, Vol 10, Issue 3, p241
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1703