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- Title
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.
- Authors
McGeachy, Mandy J; Chen, Yi; Tato, Cristina M; Laurence, Arian; Joyce-Shaikh, Barbara; Blumenschein, Wendy M; McClanahan, Terrill K; O'Shea, John J; Cua, Daniel J
- Abstract
Interleukin 23 (IL-23) is required for autoimmune inflammation mediated by IL-17-producing helper T cells (T(H)-17 cells) and has been linked to many human immune disorders. Here we restricted deficiency in the IL-23 receptor to defined cell populations in vivo to investigate the requirement for IL-23 signaling in the development and function of T(H)-17 cells in autoimmunity, inflammation and infection. In the absence of IL-23, T(H)-17 development was stalled at the early activation stage. T(H)-17 cells failed to downregulate IL-2 and also failed to maintain IL-17 production or upregulate expression of the IL-7 receptor alpha-chain. These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues.
- Publication
Nature immunology, 2009, Vol 10, Issue 3, p314
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1698