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- Title
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and T<sub>H</sub>-17 cells.
- Authors
Bauquet, Aurelie T; Jin, Hulin; Paterson, Alison M; Mitsdoerffer, Meike; Ho, I-Cheng; Sharpe, Arlene H; Kuchroo, Vijay K
- Abstract
The inducible costimulatory molecule ICOS has been suggested to be important in the development of interleukin 17 (IL-17)-producing helper T cells (TH-17 cells) and of follicular helper T cells (TFH cells). Here we show that ICOS-deficient mice had no defect in TH-17 differentiation but had fewer TH-17 cells after IL-23 stimulation and fewer TFH cells. We also show that TFH cells produced IL-17 and that TFH cells in ICOS-deficient mice were defective in IL-17 production. Both TH-17 and TFH cells had higher expression of the transcription factor c-Maf. Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer TH-17 and TFH cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of TH-17 and TFH cells.
- Publication
Nature Immunology, 2009, Vol 10, Issue 2, p167
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.1690