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- Title
RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46<sup>+</sup> cells.
- Authors
Sanos, Stephanie L; Bui, Viet L; Mortha, Arthur; Oberle, Karin; Heners, Charlotte; Johner, Caroline; Diefenbach, Andreas
- Abstract
The mucosal immune system of the intestine is separated from a vast array of microbes by a single layer of epithelial cells. Cues from the commensal microflora are needed to maintain epithelial homeostasis, but the molecular and cellular identities of these cues are unclear. Here we provide evidence that signals from the commensal microflora contribute to the differentiation of a lymphocyte population coexpressing stimulatory natural killer cell receptors and the transcription factor RORγt that produced interleukin 22 (IL-22). The emergence of these IL-22-producing RORγthiNKp46+NK1.1int cells depended on RORγt expression, which indicated that these cells may have been derived from lymphoid tissue–inducer cells. IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis.
- Publication
Nature Immunology, 2009, Vol 10, Issue 1, p83
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/ni.1684