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- Title
The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.
- Authors
Kovalovsky, Damian; Uche, Olisambu U; Eladad, Sonia; Hobbs, Robin M; Yi, Woelsung; Alonzo, Eric; Chua, Kevin; Eidson, Maggie; Kim, Hye-Jung; Im, Jin S; Pandolfi, Pier Paolo; Sant'Angelo, Derek B
- Abstract
Invariant natural killer T cells (iNKT cells) have an innate immunity-like rapidity of response and the ability to modulate the effector functions of other cells. We show here that iNKT cells specifically expressed the BTB-zinc finger transcriptional regulator PLZF. In the absence of PLZF, iNKT cells developed, but they lacked many features of innate T cells. PLZF-deficient iNKT cells accumulated in lymph nodes rather than in the liver, did not express NK markers and did not have the characteristic activated phenotype. PLZF-deficient iNKT cells failed to secrete large amounts of interleukin 4 and interferon-gamma after activation; however, some cells produced either interleukin 4 or interferon-gamma but not both. PLZF, therefore, is an iNKT cell-specific transcription factor that is necessary for full functionality.
- Publication
Nature immunology, 2008, Vol 9, Issue 9, p1055
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1641