We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.
- Authors
An, Huazhang; Hou, Jin; Zhou, Jun; Zhao, Wei; Xu, Hongmei; Zheng, Yuejuan; Yu, Yizhi; Liu, Shuxun; Cao, Xuetao
- Abstract
Unbalanced production of proinflammatory cytokines and type I interferons in immune responses may lead to immunopathology; thus, the mechanisms that ensure the beneficial production of proinflammatory cytokines and type I interferons are of particular importance. Here we demonstrate that the phosphatase SHP-1 negatively regulated Toll-like receptor-mediated production of proinflammatory cytokines by inhibiting activation of the transcription factor NF-kappaB and mitogen-activated protein kinase. Simultaneously, SHP-1 increased the production of type I interferon mediated by Toll-like receptors and the helicase RIG-I by directly binding to and inhibiting activation of the kinase IRAK1. Our data demonstrate that SHP-1 contributes to immune homeostasis by balancing the production of proinflammatory cytokines and type I interferons in the innate immune response.
- Publication
Nature immunology, 2008, Vol 9, Issue 5, p542
- ISSN
1529-2916
- Publication type
Journal Article
- DOI
10.1038/ni.1604