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- Title
A gene-driven approach to the identification of ENU mutants in the mouse.
- Authors
Coghill, Emma L; Hugill, Alison; Parkinson, Nick; Davison, Claire; Glenister, Peter; Clements, Sian; Hunter, Jackie; Cox, Roger D; Brown, Steve D M
- Abstract
The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.
- Publication
Nature genetics, 2002, Vol 30, Issue 3, p255
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng847