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Title
Identification of foreign gene sequences by transcript filtering against the human genome.
Authors
Weber, Griffin; Shendure, Jay; Tanenbaum, David M; Church, George M; Meyerson, Matthew
Abstract
We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries.