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- Title
Angptl3 regulates lipid metabolism in mice.
- Authors
Koishi, Ryuta; Ando, Yosuke; Ono, Mitsuru; Shimamura, Mitsuru; Yasumo, Hiroaki; Fujiwara, Toshihiko; Horikoshi, Hiroyoshi; Furukawa, Hidehiko
- Abstract
The KK obese mouse is moderately obese and has abnormally high levels of plasma insulin (hyperinsulinemia), glucose (hyperglycemia) and lipids (hyperlipidemia). In one strain (KK/San), we observed abnormally low plasma lipid levels (hypolipidemia). This mutant phenotype is inherited recessively as a mendelian trait. Here we report the mapping of the hypolipidemia (hypl) locus to the middle of chromosome 4 and positional cloning of the autosomal recessive mutation responsible for the hypolipidemia. The hypl locus encodes a unique angiopoietin-like lipoprotein modulator, which we named Allm1. It is identical to angiopoietin-like protein 3, encoded by Angptl3, and has a highly conserved counterpart in humans. Overexpression of Angptl3 or intravenous injection of the purified protein in KK/San mice elicited an increase in circulating plasma lipid levels. This increase was also observed in C57BL/6J normal mice. Taken together, these data suggest that Angptl3 regulates lipid metabolism in animals.
- Publication
Nature genetics, 2002, Vol 30, Issue 2, p151
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng814