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Title
Small changes in expression affect predisposition to tumorigenesis.
Authors
Yan, Hai; Dobbie, Zuzana; Gruber, Stephen B; Markowitz, Sanford; Romans, Kathy; Giardiello, Francis M; Kinzler, Kenneth W; Vogelstein, Bert
Abstract
We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.