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- Title
Genes required for ionizing radiation resistance in yeast.
- Authors
Bennett, C B; Lewis, L K; Karthikeyan, G; Lobachev, K S; Jin, Y H; Sterling, J F; Snipe, J R; Resnick, M A
- Abstract
The ability of Saccharomyces cerevisiae to tolerate ionizing radiation damage requires many DNA-repair and checkpoint genes, most having human orthologs. A genome-wide screen of diploid mutants homozygous with respect to deletions of 3,670 nonessential genes revealed 107 new loci that influence gamma-ray sensitivity. Many affect replication, recombination and checkpoint functions. Nearly 90% were sensitive to other agents, and most new genes could be assigned to the following functional groups: chromatin remodeling, chromosome segregation, nuclear pore formation, transcription, Golgi/vacuolar activities, ubiquitin-mediated protein degradation, cytokinesis, mitochondrial activity and cell wall maintenance. Over 50% share homology with human genes, including 17 implicated in cancer, indicating that a large set of newly identified human genes may have related roles in the toleration of radiation damage.
- Publication
Nature genetics, 2001, Vol 29, Issue 4, p426
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng778