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- Title
Assembly of microarrays for genome-wide measurement of DNA copy number.
- Authors
Snijders, A M; Nowak, N; Segraves, R; Blackwood, S; Brown, N; Conroy, J; Hamilton, G; Hindle, A K; Huey, B; Kimura, K; Law, S; Myambo, K; Palmer, J; Ylstra, B; Yue, J P; Gray, J W; Jain, A N; Pinkel, D; Albertson, D G
- Abstract
We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.
- Publication
Nature genetics, 2001, Vol 29, Issue 3, p263
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng754