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- Title
PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients.
- Authors
Barcellos, L F; Caillier, S; Dragone, L; Elder, M; Vittinghoff, E; Bucher, P; Lincoln, R R; Pericak-Vance, M; Haines, J L; Weiss, A; Hauser, S L; Oksenberg, J R
- Abstract
A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.
- Publication
Nature genetics, 2001, Vol 29, Issue 1, p23
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng722