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- Title
Variation in complement factor 3 is associated with risk of age-related macular degeneration.
- Authors
Maller, Julian B; Fagerness, Jesen A; Reynolds, Robyn C; Neale, Benjamin M; Daly, Mark J; Seddon, Johanna M
- Abstract
The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.
- Publication
Nature genetics, 2007, Vol 39, Issue 10, p1200
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng2131