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- Title
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.
- Authors
Menzel, Stephan; Garner, Chad; Gut, Ivo; Matsuda, Fumihiko; Yamaguchi, Masao; Heath, Simon; Foglio, Mario; Zelenika, Diana; Boland, Anne; Rooks, Helen; Best, Steve; Spector, Tim D; Farrall, Martin; Lathrop, Mark; Thein, Swee Lay
- Abstract
F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and beta thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.
- Publication
Nature genetics, 2007, Vol 39, Issue 10, p1197
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng2108