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- Title
Tissue-specific transcriptional regulation has diverged significantly between human and mouse.
- Authors
Odom, Duncan T; Dowell, Robin D; Jacobsen, Elizabeth S; Gordon, William; Danford, Timothy W; MacIsaac, Kenzie D; Rolfe, P Alexander; Conboy, Caitlin M; Gifford, David K; Fraenkel, Ernest
- Abstract
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.
- Publication
Nature genetics, 2007, Vol 39, Issue 6, p730
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng2047