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- Title
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
- Authors
Gudmundsson, Julius; Sulem, Patrick; Manolescu, Andrei; Amundadottir, Laufey T; Gudbjartsson, Daniel; Helgason, Agnar; Rafnar, Thorunn; Bergthorsson, Jon T; Agnarsson, Bjarni A; Baker, Adam; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Jakobsdottir, Margret; Xu, Jianfeng; Blondal, Thorarinn; Kostic, Jelena; Sun, Jielin; Ghosh, Shyamali; Stacey, Simon N; Mouy, Magali; Saemundsdottir, Jona; Backman, Valgerdur M; Kristjansson, Kristleifur; Tres, Alejandro; Partin, Alan W; Albers-Akkers, Marjo T; Godino-Ivan Marcos, Javier; Walsh, Patrick C; Swinkels, Dorine W; Navarrete, Sebastian; Isaacs, Sarah D; Aben, Katja K; Graif, Theresa; Cashy, John; Ruiz-Echarri, Manuel; Wiley, Kathleen E; Suarez, Brian K; Witjes, J Alfred; Frigge, Mike; Ober, Carole; Jonsson, Eirikur; Einarsson, Gudmundur V; Mayordomo, Jose I; Kiemeney, Lambertus A; Isaacs, William B; Catalona, William J; Barkardottir, Rosa B; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
- Abstract
Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.
- Publication
Nature genetics, 2007, Vol 39, Issue 5, p631
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1999