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- Title
Epigenetic stem cell signature in cancer.
- Authors
Widschwendter, Martin; Fiegl, Heidi; Egle, Daniel; Mueller-Holzner, Elisabeth; Spizzo, Gilbert; Marth, Christian; Weisenberger, Daniel J; Campan, Mihaela; Young, Joanne; Jacobs, Ian; Laird, Peter W
- Abstract
Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.
- Publication
Nature genetics, 2007, Vol 39, Issue 2, p157
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1941