We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome-wide analysis of estrogen receptor binding sites.
- Authors
Carroll, Jason S; Meyer, Clifford A; Song, Jun; Li, Wei; Geistlinger, Timothy R; Eeckhoute, Jérôme; Brodsky, Alexander S; Keeton, Erika Krasnickas; Fertuck, Kirsten C; Hall, Giles F; Wang, Qianben; Bekiranov, Stefan; Sementchenko, Victor; Fox, Edward A; Silver, Pamela A; Gingeras, Thomas R; Liu, X Shirley; Brown, Myles
- Abstract
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation, particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer.
- Publication
Nature genetics, 2006, Vol 38, Issue 11, p1289
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1901