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- Title
Nucleosome positions predicted through comparative genomics.
- Authors
Ioshikhes, Ilya P; Albert, Istvan; Zanton, Sara J; Pugh, B Franklin
- Abstract
DNA sequence has long been recognized as an important contributor to nucleosome positioning, which has the potential to regulate access to genes. The extent to which the nucleosomal architecture at promoters is delineated by the underlying sequence is now being worked out. Here we use comparative genomics to report a genome-wide map of nucleosome positioning sequences (NPSs) located in the vicinity of all Saccharomyces cerevisiae genes. We find that the underlying DNA sequence provides a very good predictor of nucleosome locations that have been experimentally mapped to a small fraction of the genome. Notably, distinct classes of genes possess characteristic arrangements of NPSs that may be important for their regulation. In particular, genes that have a relatively compact NPS arrangement over the promoter region tend to have a TATA box buried in an NPS and tend to be highly regulated by chromatin modifying and remodeling factors.
- Publication
Nature genetics, 2006, Vol 38, Issue 10, p1210
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1878