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- Title
Genome-wide genetic association of complex traits in heterogeneous stock mice.
- Authors
Valdar, William; Solberg, Leah C; Gauguier, Dominique; Burnett, Stephanie; Klenerman, Paul; Cookson, William O; Taylor, Martin S; Rawlins, J Nicholas P; Mott, Richard; Flint, Jonathan
- Abstract
Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we show that genome-wide high-resolution mapping of multiple phenotypes can be achieved using a stock of genetically heterogeneous mice. We developed a conservative and robust bootstrap analysis to map 843 QTLs with an average 95% confidence interval of 2.8 Mb. The QTLs contribute to variation in 97 traits, including models of human disease (asthma, type 2 diabetes mellitus, obesity and anxiety) as well as immunological, biochemical and hematological phenotypes. The genetic architecture of almost all phenotypes was complex, with many loci each contributing a small proportion to the total variance. Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits.
- Publication
Nature genetics, 2006, Vol 38, Issue 8, p879
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1840