We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A common variant associated with prostate cancer in European and African populations.
- Authors
Amundadottir, Laufey T; Sulem, Patrick; Gudmundsson, Julius; Helgason, Agnar; Baker, Adam; Agnarsson, Bjarni A; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Cazier, Jean-Baptiste; Sainz, Jesus; Jakobsdottir, Margret; Kostic, Jelena; Magnusdottir, Droplaug N; Ghosh, Shyamali; Agnarsson, Kari; Birgisdottir, Birgitta; Le Roux, Louise; Olafsdottir, Adalheidur; Blondal, Thorarinn; Andresdottir, Margret; Gretarsdottir, Olafia Svandis; Bergthorsson, Jon T; Gudbjartsson, Daniel; Gylfason, Arnaldur; Thorleifsson, Gudmar; Manolescu, Andrei; Kristjansson, Kristleifur; Geirsson, Gudmundur; Isaksson, Helgi; Douglas, Julie; Johansson, Jan-Erik; Bälter, Katarina; Wiklund, Fredrik; Montie, James E; Yu, Xiaoying; Suarez, Brian K; Ober, Carole; Cooney, Kathleen A; Gronberg, Henrik; Catalona, William J; Einarsson, Gudmundur V; Barkardottir, Rosa B; Gulcher, Jeffrey R; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
- Abstract
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
- Publication
Nature genetics, 2006, Vol 38, Issue 6, p652
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1808