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- Title
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.
- Authors
Bell, Daphne W; Gore, Ira; Okimoto, Ross A; Godin-Heymann, Nadia; Sordella, Raffaella; Mulloy, Roseann; Sharma, Sreenath V; Brannigan, Brian W; Mohapatra, Gayatry; Settleman, Jeff; Haber, Daniel A
- Abstract
Somatic activating mutations in EGFR identify a subset of non-small cell lung cancer that respond to tyrosine kinase inhibitors. Acquisition of drug resistance is linked to a specific secondary somatic mutation, EGFR T790M. Here we describe a family with multiple cases of non-small cell lung cancer associated with germline transmission of this mutation. Four of six tumors analyzed showed a secondary somatic activating EGFR mutation, arising in cis with the germline EGFR mutation T790M. These observations implicate altered EGFR signaling in genetic susceptibility to lung cancer.
- Publication
Nature genetics, 2005, Vol 37, Issue 12, p1315
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1671