We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
- Authors
Stephens, Philip; Edkins, Sarah; Davies, Helen; Greenman, Chris; Cox, Charles; Hunter, Chris; Bignell, Graham; Teague, Jon; Smith, Raffaella; Stevens, Claire; O'Meara, Sarah; Parker, Adrian; Tarpey, Patrick; Avis, Tim; Barthorpe, Andy; Brackenbury, Lisa; Buck, Gemma; Butler, Adam; Clements, Jody; Cole, Jennifer; Dicks, Ed; Edwards, Ken; Forbes, Simon; Gorton, Matthew; Gray, Kristian; Halliday, Kelly; Harrison, Rachel; Hills, Katy; Hinton, Jonathon; Jones, David; Kosmidou, Vivienne; Laman, Ross; Lugg, Richard; Menzies, Andrew; Perry, Janet; Petty, Robert; Raine, Keiran; Shepherd, Rebecca; Small, Alexandra; Solomon, Helen; Stephens, Yvonne; Tofts, Calli; Varian, Jennifer; Webb, Anthony; West, Sofie; Widaa, Sara; Yates, Andrew; Brasseur, Francis; Cooper, Colin S; Flanagan, Adrienne M; Green, Anthony; Knowles, Maggie; Leung, Suet Y; Looijenga, Leendert H J; Malkowicz, Bruce; Pierotti, Marco A; Teh, Bin; Yuen, Siu T; Nicholson, Andrew G; Lakhani, Sunil; Easton, Douglas F; Weber, Barbara L; Stratton, Michael R; Futreal, P Andrew; Wooster, Richard
- Abstract
We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
- Publication
Nature genetics, 2005, Vol 37, Issue 6, p590
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1571