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- Title
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.
- Authors
Yalcin, Binnaz; Willis-Owen, Saffron A G; Fullerton, Jan; Meesaq, Anjela; Deacon, Robert M; Rawlins, J Nicholas P; Copley, Richard R; Morris, Andrew P; Flint, Jonathan; Mott, Richard
- Abstract
Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a regulator of G protein signaling. We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait.
- Publication
Nature genetics, 2004, Vol 36, Issue 11, p1197
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1450