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- Title
Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes.
- Authors
Fong, Stephen S; Palsson, Bernhard Ø
- Abstract
Genome-scale metabolic models have a promising ability to describe cellular phenotypes accurately. Here we show that strains of Escherichia coli carrying a deletion of a single metabolic gene increase their growth rates (by 87% on average) during adaptive evolution and that the endpoint growth rates can be predicted computationally in 39 of 50 (78%) strains tested. These results show that computational models can be used to predict the eventual effects of genetic modifications.
- Publication
Nature genetics, 2004, Vol 36, Issue 10, p1056
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1432