We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human Alu element retrotransposition induced by genotoxic stress.
- Authors
Hagan, Christy R; Sheffield, Rebecca F; Rudin, Charles M
- Abstract
Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).
- Publication
Nature genetics, 2003, Vol 35, Issue 3, p219
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1259