We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The microRNA-producing enzyme Dicer1 is essential for zebrafish development.
- Authors
Wienholds, Erno; Koudijs, Marco J; van Eeden, Freek J M; Cuppen, Edwin; Plasterk, Ronald H A
- Abstract
MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.
- Publication
Nature genetics, 2003, Vol 35, Issue 3, p217
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1251