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- Title
Evolutionary conservation of motif constituents in the yeast protein interaction network.
- Authors
Wuchty, S; Oltvai, Z N; Barabási, A-L
- Abstract
Understanding why some cellular components are conserved across species but others evolve rapidly is a key question of modern biology. Here we show that in Saccharomyces cerevisiae, proteins organized in cohesive patterns of interactions are conserved to a substantially higher degree than those that do not participate in such motifs. We find that the conservation of proteins in distinct topological motifs correlates with the interconnectedness and function of that motif and also depends on the structure of the overall interactome topology. These findings indicate that motifs may represent evolutionary conserved topological units of cellular networks molded in accordance with the specific biological function in which they participate.
- Publication
Nature genetics, 2003, Vol 35, Issue 2, p176
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1242