We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.
- Authors
Seitz, Hervé; Youngson, Neil; Lin, Shau-Ping; Dalbert, Simone; Paulsen, Martina; Bachellerie, Jean-Pierre; Ferguson-Smith, Anne C; Cavaillé, Jérôme
- Abstract
MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.
- Publication
Nature genetics, 2003, Vol 34, Issue 3, p261
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1171