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- Title
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
- Authors
Jamain, Stéphane; Quach, Hélène; Betancur, Catalina; Råstam, Maria; Colineaux, Catherine; Gillberg, I Carina; Soderstrom, Henrik; Giros, Bruno; Leboyer, Marion; Gillberg, Christopher; Bourgeron, Thomas; Paris Autism Research International Sibpair Study
- Abstract
Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.
- Publication
Nature genetics, 2003, Vol 34, Issue 1, p27
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng1136