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- Title
Statistical false positive or true disease pathway?
- Authors
Todd, John A
- Abstract
Three very recent reports provide convincing statistical evidence (P < 10(-8)), at a genome-wide level, of the association of common polymorphisms with three different common diseases: systemic lupus erythematosus (IRF5), prostate cancer and type 1 diabetes (IFIH1 region). This adds to the trickle--soon to be a flood--of disease association results that are highly unlikely to be false positives. There are other convincing examples in the last 12 months: age-related macular degeneration (CFH), type 1 diabetes (IL2RA, also known as CD25) and type 2 diabetes (TCF7L2). Given 20 years of a literature full of irreproducible results, what has changed?
- Publication
Nature genetics, 2006, Vol 38, Issue 7, p731
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/ng0706-731