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- Title
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
- Authors
Gudmundsson, Julius; Sulem, Patrick; Rafnar, Thorunn; Bergthorsson, Jon T; Manolescu, Andrei; Gudbjartsson, Daniel; Agnarsson, Bjarni A; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Blondal, Thorarinn; Jakobsdottir, Margret; Stacey, Simon N; Kostic, Jelena; Kristinsson, Kari T; Birgisdottir, Birgitta; Ghosh, Shyamali; Magnusdottir, Droplaug N; Thorlacius, Steinunn; Thorleifsson, Gudmar; Zheng, S Lilly; Sun, Jielin; Chang, Bao-Li; Elmore, J Bradford; Breyer, Joan P; McReynolds, Kate M; Bradley, Kevin M; Yaspan, Brian L; Wiklund, Fredrik; Stattin, Par; Lindström, Sara; Adami, Hans-Olov; McDonnell, Shannon K; Schaid, Daniel J; Cunningham, Julie M; Wang, Liang; Cerhan, James R; St Sauver, Jennifer L; Isaacs, Sara D; Wiley, Kathleen E; Partin, Alan W; Walsh, Patrick C; Polo, Sonia; Ruiz-Echarri, Manuel; Navarrete, Sebastian; Fuertes, Fernando; Saez, Berta; Godino, Javier; Weijerman, Philip C; Swinkels, Dorine W; Aben, Katja K; Witjes, J Alfred; Suarez, Brian K; Helfand, Brian T; Frigge, Michael L; Kristjansson, Kristleifur; Ober, Carole; Jonsson, Eirikur; Einarsson, Gudmundur V; Xu, Jianfeng; Gronberg, Henrik; Smith, Jeffrey R; Thibodeau, Stephen N; Isaacs, William B; Catalona, William J; Mayordomo, Jose I; Kiemeney, Lambertus A; Barkardottir, Rosa B; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
- Abstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
- Publication
Nature genetics, 2008, Vol 40, Issue 3, p281
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.89