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- Title
Subspecific origin and haplotype diversity in the laboratory mouse.
- Authors
Hyuna Yang; Wang, Jeremy R.; Didion, John P.; Buus, Ryan J.; Bell, Timothy A.; Welsh, Catherine E.; Bonhomme, François; Yu, Alex Hon-Tsen; Nachman, Michael W.; Pialek, Jaroslav; Tucker, Priscilla; Boursot, Pierre; McMillan, Leonard; Churchill, Gary A.; de Villena, Fernando Pardo-Manuel
- Abstract
Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin, and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and show that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains, and contamination by laboratory stocks has played a role in this process. The subspecific origin, haplotype diversity and identity by descent maps can be visualized using the Mouse Phylogeny Viewer (see URLs).
- Publication
Nature Genetics, 2011, Vol 43, Issue 7, p648
- ISSN
1061-4036
- Publication type
Academic Journal
- DOI
10.1038/ng.847