We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
- Authors
Kumar, Vinod; Kato, Naoya; Urabe, Yuji; Takahashi, Atsushi; Muroyama, Ryosuke; Hosono, Naoya; Otsuka, Motoyuki; Tateishi, Ryosuke; Omata, Masao; Nakagawa, Hidewaki; Koike, Kazuhiko; Kamatani, Naoyuki; Kubo, Michiaki; Nakamura, Yusuke; Matsuda, Koichi
- Abstract
To identify the genetic susceptibility factor(s) for hepatitis C virus-induced hepatocellular carcinoma (HCV-induced HCC), we conducted a genome-wide association study using 432,703 autosomal SNPs in 721 individuals with HCV-induced HCC (cases) and 2,890 HCV-negative controls of Japanese origin. Eight SNPs that showed possible association (P < 1 × 10(-5)) in the genome-wide association study were further genotyped in 673 cases and 2,596 controls. We found a previously unidentified locus in the 5' flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 × 10(-13), odds ratio = 1.39) to be strongly associated with HCV-induced HCC. Subsequent analyses using individuals with chronic hepatitis C (CHC) indicated that this SNP is not associated with CHC susceptibility (P = 0.61) but is significantly associated with progression from CHC to HCC (P = 3.13 × 10(-8)). We also found that the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals with HCV-induced HCC (P = 1.38 × 10(-13)).
- Publication
Nature genetics, 2011, Vol 43, Issue 5, p455
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.809