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- Title
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
- Authors
Peden, John F; Hopewell, Jemma C; Saleheen, Danish; Chambers, John C; Hager, Jorg; Soranzo, Nicole; Collins, Rory; Danesh, John; Elliott, Paul; Farrall, Martin; Stirrups, Kathy; Zhang, Weihua; Hamsten, Anders; Parish, Sarah; Lathrop, Mark; Watkins, Hugh; Clarke, Robert; Deloukas, Panos; Kooner, Jaspal S; Goel, Anuj
- Abstract
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD), a modest number considering the apparent heritability of CAD. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ?575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10?8 in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.
- Publication
Nature Genetics, 2011, Vol 43, Issue 4, p339
- ISSN
1061-4036
- Publication type
Academic Journal
- DOI
10.1038/ng.782