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- Title
The draft genome of the parasitic nematode Trichinella spiralis.
- Authors
Mitreva, Makedonka; Jasmer, Douglas P; Zarlenga, Dante S; Wang, Zhengyuan; Abubucker, Sahar; Martin, John; Taylor, Christina M; Yin, Yong; Fulton, Lucinda; Minx, Pat; Yang, Shiaw-Pyng; Warren, Wesley C; Fulton, Robert S; Bhonagiri, Veena; Zhang, Xu; Hallsworth-Pepin, Kym; Clifton, Sandra W; McCarter, James P; Appleton, Judith; Mardis, Elaine R; Wilson, Richard K
- Abstract
Genome evolution studies for the phylum Nematoda have been limited by focusing on comparisons involving Caenorhabditis elegans. We report a draft genome sequence of Trichinella spiralis, a food-borne zoonotic parasite, which is the most common cause of human trichinellosis. This parasitic nematode is an extant member of a clade that diverged early in the evolution of the phylum, enabling identification of archetypical genes and molecular signatures exclusive to nematodes. We sequenced the 64-Mb nuclear genome, which is estimated to contain 15,808 protein-coding genes, at ∼35-fold coverage using whole-genome shotgun and hierarchal map-assisted sequencing. Comparative genome analyses support intrachromosomal rearrangements across the phylum, disproportionate numbers of protein family deaths over births in parasitic compared to a non-parasitic nematode and a preponderance of gene-loss and -gain events in nematodes relative to Drosophila melanogaster. This genome sequence and the identified pan-phylum characteristics will contribute to genome evolution studies of Nematoda as well as strategies to combat global parasites of humans, food animals and crops.
- Publication
Nature genetics, 2011, Vol 43, Issue 3, p228
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.769