We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Overexpression of Fto leads to increased food intake and results in obesity.
- Authors
Church, Chris; Moir, Lee; McMurray, Fiona; Girard, Christophe; Banks, Gareth T; Teboul, Lydia; Wells, Sara; Brüning, Jens C; Nolan, Patrick M; Ashcroft, Frances M; Cox, Roger D
- Abstract
Genome-wide association studies have identified SNPs within FTO, the human fat mass and obesity-associated gene, that are strongly associated with obesity. Individuals homozygous for the at-risk rs9939609 A allele weigh, on average, ~3 kg more than individuals with the low-risk T allele. Mice that lack FTO function and/or Fto expression display increased energy expenditure and a lean phenotype. We show here that ubiquitous overexpression of Fto leads to a dose-dependent increase in body and fat mass, irrespective of whether mice are fed a standard or a high-fat diet. Our results suggest that increased body mass results primarily from increased food intake. Mice with increased Fto expression on a high-fat diet develop glucose intolerance. This study provides the first direct evidence that increased Fto expression causes obesity in mice.
- Publication
Nature genetics, 2010, Vol 42, Issue 12, p1086
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.713